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Prostate Cancer treatment details. Biologic therapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 18.4 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 9/2012

Description:
Patients:
This phase 3 study involved 800 men with castration-resistant prostate cancer who had undergone chemotherapy. The median patient age was 69 years.

Treatment:
Patients were treated with the biologic therapy agent enzalutamide, an inhibitor of the androgen-receptor-signaling pathway in cells, which is involved in prostate cancer growth.

Toxicities:
There were 23 treatment-related deaths due to unspecified causes. Grade 3 or higher fatigue, cardiac disorder, and seizure were also reported.

Results:
The median overall survival was 18.4 months.

Support:
This study was supported by Medivation and Astellas Pharma Global Development.

Correspondence: Dr. Howard I. Scher; email: scherh@mskcc.org

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