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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Royal Free and University College Medical School, London, United Kingdom



Survival: N/R
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: London
   
Hospital: Royal Free and University College Medical School
   
Journal: Link
   
Date: 8/2002

Description:
Patients: This Phase I study involved 27 patients of which 25 had advanced colorectal cancer.

Treatment: The treatment consisted of antibody-directed enzyme prodrug therapy (ADEPT) in which a prodrug (bis-iodo phenol mustard, ZD2767P) is activated selectively at the tumour site by an enzyme, which has been targeted to the tumour by an antibody (antibody-enzyme conjugate).

Toxicity: Patients in this maximum tolerated dose study experienced grade 4 thrombocytopenia. Other toxicities included neutropenia, leucopenia, nausea, malaise, and fever.

Results: There were no objective responses in this study.

Support: This study was supported by AstraZeneca.

Correspondence: R.J. Francis

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