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Bladder Cancer treatment details. Biologic therapy. Chemotherapy. Fox Chase Cancer Center, Philadelphia, PA, United States



Survival: 9.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Philadelphia, PA
   
Hospital: Fox Chase Cancer Center
   
Journal: Link
   
Date: 10/2012

Description:
Patients:
This phase 2 study involved previously treated advanced urothelial tract carcinoma patients who were divided into two separated treatment groups. Group A consisted of 11 patients with a median age of 70 years; 9 were male. Group B had 28 patients with a median age of 69 years; 21 were male.

Treatment:
Patients in group A were treated with the biologic therapy agent cetuximab, which is a monoclonal antibody that targets cancer cells to be killed by the immune system.

Patients in group B were treated with cetuximab and the chemotherapy agent paclitaxel.

Toxicities:
The maximum toxicity grade in group A was grade 4 and included grade 3-4 rash, diarrhea, and fatigue.

Treatment-related deaths were reported in group B but specific causes were not given. Grade 3-4 rash, fatigue, and low magnesium levels were also reported.

Results:
The median overall survival rates for groups A and B were 3.9 and 9.7 months, respectively.

Support:
This study was partially supported by Bristol Myers Squibb.

Correspondence: Dr. Yu-Ning Wong; email: yu-ning.wong@fccc.edu

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