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Lung Cancer treatment details. Biologic therapy. Chemotherapy. University Medical Center Groningen, Groningen, Netherlands



Survival: 8.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Netherlands
   
City/State/Province: Groningen
   
Hospital: University Medical Center Groningen
   
Journal: Link
   
Date: 11/2011

Description:
Patients:
This phase 3 study involved advanced non-small cell lung cancer patients, who had not been previously treated with chemotherapy and were divided into two separate treatment groups. Group A consisted of 281 patients with a median age of 62 years; 65% were male. Group B had 280 patients, 61% male, and a median patient age of 61 years.

Treatment:
Patients in group A were treated with the chemotherapy agents docetaxel and carboplatin, as well as the biologic therapy agent celecoxib (also known as Celebrex), which is an anti-inflammatory medicine.

Patients in group B were treated with docetaxel and carboplatin only.

Toxicities:
Treatment-related deaths due to unspecified causes were reported in group A. Grade 3-4 neutropenia, fatigue, and leukopenia were also reported.

Treatment-related deaths due to unspecified causes were reported in group B. Grade 3-4 neutropenia, fatigue, and leukopenia were also reported.

Results:
The median overall survival rate for both group A and group B was 8.2 months.

Support:
This study was supported by the pharmaceutical company Pfizer.

Correspondence: Dr. Harry J.M. Groen; email: h.j.m.groen@long.umcg.nl

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