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Rectal Cancer treatment details. Chemotherapy. Radiation. Martin-Luther-Universitat, Halle, Germany

Survival: ?
Toxicity Grade: 3
Treatments: Chemotherapy
Drugs: Xeloda
Country: Germany
City/State/Province: Halle
Hospital: Martin-Luther-Universitat
Journal: Link
Date: 10/2002

Patients: This Phase I study involved 36 patients. 92% of patients had newly diagnosed rectal cancer.

Treatment: Treatment consisted of concurrent radiotherapy and the chemotherapy drug Capecitabine (xeloda).

Toxicity: Patients in this maximum tolerated dose study experienced grade 3 hand-foot syndrome, skin rash and perinatal toxicity. Other toxicities (less than grade 3) included: hematologic, infection, gastrointestinal, hepatic, genitourinary, alopecia, cardiovascular, neurologic, flu-like symptoms, metabolic, endocrine, and ocular.

Results: A clinical partial response was reported in nine of ten patients. Overall survival was not discussed.

Support: This study was supported in part by a grant from Hoffman-La Roche.

Correspondence: Jurgen Dunst, MD

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