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Brain Cancer treatment details. Biologic therapy. Radiation. Dana-Farber/Brigham and Women’s Cancer Center, Boston, MA, United States



Survival: 10.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Dana-Farber/Brigham and Women’s Cancer Center
   
Journal: Link
   
Date: 10/2012

Description:
Patients:
This phase 2 study involved 89 newly diagnosed glioblastoma patients. The median patient age was not given but 62% were male.

Treatment:
Patients were treated with radiation therapy and the biologic therapy agent thalidomide (an antiangiogenic drug that targets tumor blood supply).

Toxicities:
The most severe toxicities were of grade 4. Grade 3-4 toxicities included blood clots, skin reactions, and neurological disorders.

Results:
The median overall survival was 10 months.

Support:
One of the authors has been involved as a consultant or advisor for several pharmaceutical companies.

Correspondence: Dr. Brian M. Alexander; email: bmalexander@lroc.harvard.edu

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