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Breast Cancer treatment details. Biologic therapy. Chemotherapy. St. Louis Cancer and Breast Institute, St. Louis, MO, United States



Survival: 21.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: St. Louis, MO
   
Hospital: St. Louis Cancer and Breast Institute
   
Journal: Link
   
Date: 10/2012

Description:
Patients:
This phase 2 study involved 52 female metastatic breast cancer patients. The median patient age was 55 years.

Treatment:
Patients were treated with the chemotherapy agent gemcitabine and the biologic therapy agent bevacizumab.

Toxicities:
There was one adverse event-related death due to heart attack. Grade 4 neutropenia and leukopenia were reported. Also, 51.9% of patients reported nausea, 46.2% reported fatigue, and 13.5% reported alopecia.

Results:
The median overall survival was 21 months.

Support:
This study was supported by the pharmaceutical companies Eli Lilly and Genentech/Roche.

Correspondence: Dr. Denise A. Yardley; email: dyardley@tnonc.com

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