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Colon Cancer treatment details. Biologic therapy. Istituto Clinico Humanitas, Rozzano, Italy



Survival: 13.1 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Italy
   
City/State/Province: Rozzano
   
Hospital: Istituto Clinico Humanitas
   
Journal: Link
   
Date: 10/2010

Description:
Patients:
This phase 2 study involved 33 previously-treated metastatic colorectal cancer patients with a median age of 65 years; 48.5% of the patients were male.

Treatment:
Patients were treated with asparagine-glycine-arginine-tagged human tumor necrosis factor alpha (NGR-hTNF), which is a biological therapy agent that targets tumor blood vessels to cause tumor cell death.

Toxicities:
The most severe toxicities were of grade 4 and included liver failure. Grade 1 and 2 pain, chills, and diarrhea were also reported.

Results:
The median overall survival was 13.1 months.

Support:
This study was supported by the biotechnology company MolMed.

Correspondence: Dr. Claudio Bordignon; email: claudio.bordignon@hsr.it

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