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Colon Cancer treatment details. Chemotherapy. University Hospital Gasthuisberg, Leuven, Belgium

Survival: 12.0 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Leucovorin
Country: Belgium
City/State/Province: Leuven
Hospital: University Hospital Gasthuisberg
Journal: Link
Date: 10/2012

This phase 3 study involved metastatic colorectal carcinoma patients who were divided into two separate treatment groups. Group A included 614 patients, 57.5% male, with a median age of 61 years. Group B had 612 patients, 59.6% male, with a median age of 61 years.

Patients in group A were treated with the chemotherapy combination called FOLFIRI (fluorouracil, leucovorin, and irinotecan) and a placebo.

Patients in group B were treated with the FOLFIRI chemotherapy combination and the biologic therapy agent aflibercept, a VEGF inhibitor that interferes with tumor blood supply.

The most severe toxicities in group A were of grade 4 and included infection, blood clotting, and neutropenia.

The most severe toxicities in group B were of grade 4 and included stomatitis (inflammation of the lining of the GI tract), hemorrhage, blood clotting, and neutropenia.

The median overall survival rates for groups A and B were 12.06 and 13.5 months, respectively.

This study was supported by Sanofi and Regeneron.

Correspondence: Dr. Eric Van Cutsem; email:

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