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Liver Cancer treatment details. Biologic therapy. National Taiwan University Hospital, Taipei, Taiwan Region



Survival: 6.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Taiwan Region
   
City/State/Province: Taipei
   
Hospital: National Taiwan University Hospital
   
Journal: Link
   
Date: 5/2012

Description:
Patients:
This phase 2 study involved 19 advanced hepatocellular carcinoma patients, 18 of whom were male. The median patient age was 54 years.

Treatment:
Patients were treated with the biologic therapy agent vandetanib, which is a VEGF inhibitor that interferes with tumor blood supply.

Toxicities:
The most severe toxicities were of grade 4 and included diarrhea, liver failure, and hand-foot skin reaction.

Results:
The median overall survival was 5.95 months.

Support:
This study was supported by AstraZeneca.

Correspondence: Dr. Ann-Lii Cheng; email: alcheng@ntu.edu.tw

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