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Liver Cancer treatment details. Biologic therapy. Chemotherapy. Johns Hopkins School of Medicine, Baltimore, MD, United States



Survival: 10.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Baltimore, MD
   
Hospital: Johns Hopkins School of Medicine
   
Journal: Link
   
Date: 11/2012

Description:
Patients:
This phase 2 study involved 26 hepatocellular carcinoma patients, 21 of whom were males. The median patient age was 64 years.

Treatment:
Patients were treated with the biologic therapy agent bevacizumab in addition to chemoembolization (chemotherapy delivered directly to the tumor) with unspecified drugs.

Toxicities:
There was one treatment-related death due to bowel perforation and sepsis. Grade 3-4 leukopenia, fatigue, and pain were also reported.

Results:
The median overall survival was 10.8 months.

Support:
This study was supported by Genentech and Biosphere Medical.

Correspondence: Dr. Jean-Francois H. Geschwind; email: jfg@jhmi.edu

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