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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. University of Bologna, Bologna, Italy



Survival: 37.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: Italy
   
City/State/Province: Bologna
   
Hospital: University of Bologna
   
Journal: Link
   
Date: 10/2012

Description:
Patients:
This phase 3 study involved follicular lymphoma patients who were divided into two separate treatment groups. Group A consisted of 103 patients with a median age of 61 years and 51% male. Group B consisted of 98 patients with a median age of 60 years and 43% male.

Treatment:
Patients in group A were treated with the biologic therapy agents bortezomib (a proteasome inhibitor) and rituximab (a monoclonal antibody for CD20 that causes the immune system to attack tumor cells).

Patients in group B were treated with rituximab only.

Toxicities:
There were two treatment-related deaths in group A due to septic shock and pneumonia. Grade 3 or higher diarrhea, neutropenia, and infection were also reported.

There was one treatment-related death in group B due to meningitis. Grade 3 or higher infection, neutropenia, and anemia were also reported.

Results:
The median overall survival rates for groups A and B were 37.8 and 41.5 months, respectively.

Support:
This study was supported by Johnson & Johnson Pharmaceutical Research & Development and Millennium Pharmaceuticals, Inc.

Correspondence: Dr. Pier Luigi Zinzani; email: pierluigi.zinzani@unibo.it

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