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Brain Cancer treatment details. Biologic therapy. Dana Farber/Brigham and Women’s Cancer Center, Boston, MA, United States

Survival: 6.5 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Boston, MA
Hospital: Dana Farber/Brigham and Women’s Cancer Center
Journal: Link
Date: 4/2011

This phase 2 study involved 40 recurrent glioblastoma patients who had been previously treated. The median patient age was 54 years and 63% were male.

Patients were treated with the biologic therapy agent called AMG 102 (also known as rilotumumab), a monoclonal antibody against the HGF/SF protein that inhibits tumor growth.

The most severe toxicities were grade 3/4 fatigue and edema (swelling). Nausea, dry skin, and diarrhea were also reported.

The median overall survival was 6.5 months.

This study was supported by Amgen, Inc., makers of the study drug.

Correspondence: Dr. Patrick Y. Wen; email:

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