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Brain Cancer treatment details. Biologic therapy. Dana Farber/Brigham and Women’s Cancer Center, Boston, MA, United States



Survival: 6.5 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Dana Farber/Brigham and Women’s Cancer Center
   
Journal: Link
   
Date: 4/2011

Description:
Patients:
This phase 2 study involved 40 recurrent glioblastoma patients who had been previously treated. The median patient age was 54 years and 63% were male.

Treatment:
Patients were treated with the biologic therapy agent called AMG 102 (also known as rilotumumab), a monoclonal antibody against the HGF/SF protein that inhibits tumor growth.

Toxicities:
The most severe toxicities were grade 3/4 fatigue and edema (swelling). Nausea, dry skin, and diarrhea were also reported.

Results:
The median overall survival was 6.5 months.

Support:
This study was supported by Amgen, Inc., makers of the study drug.

Correspondence: Dr. Patrick Y. Wen; email: patrick_wen@dfci.harvard.edu

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