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Colon Cancer treatment details. Chemotherapy. Surgery. Aichi Cancer Center Hospital, Nagoya, Japan

Survival: ?
Toxicity Grade: 2
Treatments: Chemotherapy
Country: Japan
City/State/Province: Nagoya
Hospital: Aichi Cancer Center Hospital
Journal: Link
Date: 2/2002

Patients: This trial involved 289 patients (“full-analysis set”) with Dukes B or C colorectal cancer. Patients were divided into two groups: UFT group and Control group. The UFT group contained 65 patients with Dukes stage B cancer and 80 patients with Dukes stage C. The control group contained 68 patients with Dukes stage B and 76 patients with Dukes stage C.

Treatment: The UFT group received curative resection (i.e. surgery) followed by the chemotherapy drugs Uracil and Tegafur. The control group received surgery alone.

Toxicity: No grade 3 toxicity was observed. Grade 1 and 2 toxicities included: leucopenia, thrombocytopenia, Liver enzymes (AST, ALT), anorexia, pigmentation, nausea/vomiting, and diarrhea.

Results: The 5-year survival rate was 80.4% in the UFT group and 76.5% in the control group. During follow-up recurrence was confirmed in 71 patients. Overall median survival was not presented.

Support: The study was supported by Taiho Pharmaceutical Co. Ltd, Tokyo.

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