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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Martin Luther University Halle-Wittenberg, Halle, Germany



Survival: 21.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs: Leucovorin
Country: Germany
   
City/State/Province: Halle
   
Hospital: Martin Luther University Halle-Wittenberg
   
Journal: Link
   
Date: 10/2012

Description:
Patients:
This phase 3 study involved untreated metastatic colorectal cancer patients who were divided into two separate treatment groups. Group A consisted of 709 patients with a median age of 59 years and 58% male. Group B had 713 patients with a median age of 60 years and 58% male.

Treatment:
Patients in group A were treated with a combination of the chemotherapy agents oxaliplatin, leucovorin, and fluorouracil, as well as the biologic therapy agent cediranib, a tyrosine kinase inhibitor that interferes with tumor growth.

Patients in group A were treated with a combination of the chemotherapy agents oxaliplatin, leucovorin, and fluorouracil, as well as the biologic therapy agent bevacizumab.

Toxicities:
Treatment-related deaths due to unspecified causes were reported for 2.7% of the patients in group A. Grade 3/4 diarrhea, neutropenia, and nerve disorders were also reported.

Treatment-related deaths due to unspecified causes were reported for 3.1% of the patients in group B. Grade 3/4 diarrhea, neutropenia, and nerve disorders were also reported.

Results:
The median overall survival rates for groups A and B were 22.8 and 21.3 months, respectively.

Support:
This study was supported by AstraZeneca, makers of cediranib.

Correspondence: Dr. Hans Joachim Schmoll; email: hans-joachim.schmoll@uk-halle.de

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