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Melanoma treatment details. Biologic therapy. University of California, Irvine, Orange, CA, United States



Survival: 6.6 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Orange, CA
   
Hospital: University of California, Irvine
   
Journal: Link
   
Date: 12/2011

Description:
Patients:
This phase 2 study involved 32 metastatic melanoma patients. The median patient age was 65 years and 53.1% were male.

Treatment:
Patients were treated with the biologic therapy agent called axitinib, an inhibitor of the VEGFR protein that interferes with cancer cell growth.

Toxicities:
There was one treatment-related death due to bowel perforation. Grade 3-4 fatigue and high blood pressure were also reported.

Results:
The median overall survival was 6.6 months.

Support:
Some of the authors are employed by or receive funding from Pfizer, Inc.

Correspondence: Dr. John Fruehauf; email: johnfruehauf@msn.com

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