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Mesothelioma Cancer treatment details. Biologic therapy. University of Arizona Cancer Center, Tucson, AZ, United States

Survival: 10.0 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Tucson, AZ
Hospital: University of Arizona Cancer Center
Journal: Link
Date: 6/2007

This phase 2 study involved 64 malignant pleural mesothelioma patients who had not received prior chemotherapy. The median patient age was 69.5 years and 75% were male.

Patients were treated with the biologic therapy agent called erlotinib, which is a tyrosine kinase inhibitor that interferes with tumor growth.

There was one treatment-related death due to shortness of breath/respiratory failure. Grade 3 rash, diarrhea, and fatigue were also reported.

The median overall survival was 10 months.

Some of the authors have served as consultants for Genentech, makers of erlotinib.

Correspondence: Southwest Oncology Group; email:

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