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Ovarian Cancer treatment details. Chemotherapy. Oslo University Hospital, Oslo, Norway



Survival: 42.4 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: Norway
   
City/State/Province: Oslo
   
Hospital: Oslo University Hospital
   
Journal: Link
   
Date: 10/2012

Description:
Patients:
This phase 3 study involved previously untreated advanced ovarian cancer patients who were divided into two separate treatment groups. Group A consisted of 445 patients with a median age of 57 years. Group B had 442 patients with a median age of 58 years.

Treatment:
Patients in group A were treated with the chemotherapy agents carboplatin, paclitaxel, and epirubicin.

Patients in group B were treated with the chemotherapy agents carboplatin and paclitaxel.

Toxicities:
The most severe toxicities in group A were of grade 4 and included vomiting and anemia. Grade 3 febrile neutropenia and nausea were also reported.

The most severe toxicities in group B were of grade 4 and included allergic reaction and anemia. Grade 3 joint pain was also reported.

Results:
The median overall survival rates for groups A and B were 42.4 and 40.2 months, respectively.

Support:
This study was supported by Pharmacia-Upjohn.

Correspondence: Dr. G. B. Kristensen; email: gunnar.b.kristensen@gmail.com

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