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Colon Cancer treatment details. Biologic therapy. University of California, Los Angeles, Santa Monica, CA, United States



Survival: 7.1 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Santa Monica, CA
   
Hospital: University of California, Los Angeles
   
Journal: Link
   
Date: 4/2010

Description:
Patients:
This study involved metastatic colorectal cancer patients who were divided into two separate patient groups based on the level of the epidermal growth factor receptor (EGFR) protein in their cancer cells. Group A had 203 patients whose cancer was classified as low or negative EGFR status. The median patient age was 61 years and 56% were male. Group B had 185 patients with high EGFR status. The median patient age was 60 years and 54% were male.

Treatment:
Patients in both groups were treated with the biologic therapy agent panitumumab, which is an antibody for the EGFR protein and inhibits cancer cell growth.

Toxicities:
Treatment-related deaths due to pneumonia and stroke were reported. Grade 3 skin reactions were also reported in group A.

Treatment-related deaths due to pneumonia and stroke were reported. Grade 4 fatigue and nausea were also reported in group B.

Results:
The median overall survival for groups A and B was 8.6 and 7.1 months, respectively.

Support:
This study was supported by the pharmaceutical company Amgen.

Correspondence: Dr. J. Randolph Hecht; email: jrhecht@mednet.ucla.edu

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