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Colon Cancer treatment details. Chemotherapy. Centre Régional de Lutte contre le Cancer Val d'Aurelle, Montpellier, France



Survival: 36.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs: Leucovorin
Country: France
   
City/State/Province: Montpellier
   
Hospital: Centre Régional de Lutte contre le Cancer Val d'Aurelle
   
Journal: Link
   
Date: 7/2008

Description:
Patients:
This phase 2 study involved 34 metastatic colorectal cancer patients who had metastases to the liver. The median patient age was 58 years and 64.7% were male.

Treatment:
Patients were treated with the chemotherapy regimen called FOLFIRINOX, which includes oxaliplatin, irinotecan, leucovorin, and fluorouracil.

Toxicities:
The most severe toxicities were of grade 4 and included neutropenia and vomiting. Grade 3 diarrhea, fatigue, and abdominal cramping were also reported.

Results:
The median overall survival was 36 months.

Support:
This study was supported by Aventis and Pfizer.

Correspondence: Dr. M. Ychou; email: marc.ychou@valdorel.fnclcc.fr

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