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Liver Cancer treatment details. Biologic therapy. UniversitÓ Cattolica del Sacro Cuore, Rome, Italy



Survival: 5.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: Italy
   
City/State/Province: Rome
   
Hospital: UniversitÓ Cattolica del Sacro Cuore
   
Journal: Link
   
Date: 2/2013

Description:
Patients:
This phase 2 study involved 34 advanced hepatocellular carcinoma patients who had not been previously treated. The median patient age was 68 years and 91.2% were male.

Treatment:
Patients were treated with the biologic therapy agent sunitinib, which is a tyrosine kinase inhibitor that interferes with cancer cell growth.

Toxicities:
There were six treatment-related deaths reported, the causes of which included cirrhosis and liver failure that may not have been related to liver cancer. Grade 4 gastrointestinal bleeding and thrombocytopenia, as well as grade 3 fatigue were also reported.

Results:
The median overall survival was 5.8 months.

Support:
This study was partially supported by Pfizer.

Correspondence: Dr. Carlo Barone; email: carlobarone@rm.unicatt.it

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