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Melanoma treatment details. Biologic therapy. Chemotherapy. Mayo Clinic Rochester, Rochester, MN, United States



Survival: 8.6 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic Rochester
   
Journal: Link
   
Date: 1/2013

Description:
Patients:
This phase 2 study involved 48 metastatic malignant melanoma patients with a median age of 60 years; 66% were male.

Treatment:
Patients were treated with the chemotherapy agent temozolomide and the biologic therapy agent everolimus, which is classified as an mTOR inhibitor and interferes with cancer cell growth.

Toxicities:
The most severe toxicities were of grade 4 and included neutropenia and thrombocytopenia. Grade 2-3 fatigue and anorexia were also reported.

Results:
The median overall survival was 8.6 months. The median progression-free survival was 2.4 months.

Correspondence: Dr. Svetomir N. Markovic; email: markovic.svetomir@mayo.edu

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