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Melanoma treatment details. Chemotherapy. Mayo Clinic, Rochester, MN, United States

Survival: 11.1 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: United States
City/State/Province: Rochester, MN
Hospital: Mayo Clinic
Journal: Link
Date: 4/2011

This phase 2 study involved metastatic melanoma patients who were divided into two separate groups. Group A had 34 previously treated patients with a median age of 60 years and 67.6% male. Group B consisted of 39 patients who had not previously received chemotherapy; the median patient age was 59 years and 59% were male.

Patients in group A and in group B were treated with the chemotherapy agents nab-paclitaxel and carboplatin.

The most severe toxicities in group A were of grade 4 and included grade 3-4 neutropenia and leukopenia. Anemia, fatigue, nausea, and nerve disorders were also reported.

There was one treatment-related death in group B due to infection and diarrhea. Fatigue, nausea, and nerve disorders were also reported.

The median overall survival for groups A and B was 10.9 and 11.1 months, respectively.

Correspondence: Dr. Lisa A. Kottschade; email:

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