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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. Hormone. Kyungpook National University Hospital, Jung-Gu, Daegu, Korea



Survival: 8.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Hormone
   
Drugs:
Country: Korea
   
City/State/Province: Jung-Gu, Daegu
   
Hospital: Kyungpook National University Hospital
   
Journal: Link
   
Date: 6/2007

Description:
Patients:
This phase 2 study involved 20 peripheral T-cell lymphoma patients. The median patient age was 50.5 years and 14 were male.

Treatment:
Patients were treated with the chemotherapy agents cyclophosphamide, doxorubicin, and vincristine, the hormone prednisone, and the biologic therapy agent alemtuzumab (an antibody against the CD52 protein that helps the immune system attack cancer cells).

Toxicities:
Treatment-related deaths due to pneumonia and sudden death were reported. At least 90% of the patients experienced grade 4 neutropenia, leucopenia, and/or thrombocytopenia. Nausea, vomiting, and constipation were also reported.

Results:
The median overall survival was 8.7 months.

Correspondence: Dr. Sang Kyun Sohn; email: sksohn@knu.ac.kr

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