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Ovarian Cancer treatment details. Biologic therapy. University of Texas MD Anderson Cancer Center, Houston, TX, United States



Survival: 14.9 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: University of Texas MD Anderson Cancer Center
   
Journal: Link
   
Date: 6/2012

Description:
Patients:
This phase 2 study involved 13 patients with low-grade serous carcinoma (LGSC) of the ovary, peritoneum, or fallopian tube who had previously been treated with platinum- and taxane-based chemotherapy. The median patient age was 52 years.

Treatment:
Patients were treated with the biologic therapy agent imatinib mesylate, which is a tyrosine kinase inhibitor that interferes with cancer cell growth.

Toxicities:
The most severe toxicities were of grade 3 and included granulocytopenia and rash. Grade 1-2 fatigue (66% of patients), nausea/vomiting (66%), and diarrhea (41%) were also reported.

Results:
The median overall survival was 14.9 months.

Correspondence: Dr. David M. Gershenson; email: dgershen@mdanderson.org

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