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Colon Cancer treatment details. Biologic therapy. Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada

Survival: N/R
Toxicity Grade: 3
Treatments: Biologic therapy
Country: Canada
City/State/Province: Ottawa, Ontario
Hospital: Ottawa Regional Cancer Centre
Journal: Link
Date: 7/2002

Patients: This Phase II study involved 37 treated patients with locally advanced or metastatic colorectal cancer. Twenty-eight patients had metastasis to the liver. Nineteen patients were administered one new agent (ISIS 3521) and eighteen patients received another new agent (ISIS 5132).

Treatment: The trial evaluated two biological agents: (a) ISIS 3521, an antisense inhibitor of the protein kinase C alpha; and (b) ISIS 5132, an antisense inhibitor of c-raf kinase.

Toxicity: The toxicity experienced by patients who received ISIS 3521 included: fatigue (grade 1-2), anorexia (grade 1-3), nausea (grade 1, 3), vomiting (grade 1-2), stomatitis (grade 1-2), diarrhea (grade 1), altered mood (grade 1-2), hemoglobin (grade 1-2), platelets (grade 1-2), creatinine (grade 1), and liver enzymes (grade 1-2).

Results: There were no complete or partial responses.

Support: ISIS pharmaceuticals supported the study.

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