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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Duke University Medical Center, Durham, NC, United States



Survival: 11.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Durham, NC
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 4/2013

Description:
Patients:
This phase 2 study involved 41 unresectable glioblastoma patients who had not been previously treated. The median patient age was 59.1 years and 26 were male.

Treatment:
Patients were treated with the chemotherapy agent temozolomide and the biologic therapy agent bevacizumab.

Toxicities:
There was one treatment-related death due to heart attack. Grade 4 neutropenia, blood clot, and fatigue were also reported.

Results:
The median overall survival was 11.7 months.

Support:
This study was partially supported by Genentech Pharmaceuticals.

Correspondence: Dr. Emil Lou; email: emil-lou@umn.edu

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