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Breast Cancer treatment details. Biologic therapy. The Sarah Cannon Research Institute and Tennessee Oncology, Nashville, TN, United States



Survival: 15.6 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Nashville, TN
   
Hospital: The Sarah Cannon Research Institute and Tennessee Oncology
   
Journal: Link
   
Date: 12/2012

Description:
Patients:
This phase 2 study involved 83 women with metastatic or advanced breast cancer. The median patient age was 58 years.

Treatment:
Patients were treated with the biologic therapy agent sunitinib, a tyrosine kinase inhibitor that interferes with blood supply to the tumor.

Toxicities:
There were two treatment-related deaths due to pulmonary embolism and heart attack. Grade 3-4 fatigue, neutropenia, and thrombocytopenia were also reported.

Results:
The median overall survival was 15.6 months.

Support:
This study was supported by Pfizer, Inc.

Correspondence: Dr. Denise A. Yardley; email: dyardley@tnonc.com

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