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Breast Cancer treatment details. Biologic therapy. Dana-Farber Cancer Institute, Boston, MA, United States



Survival: 14.0 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Dana-Farber Cancer Institute
   
Journal: Link
   
Date: 6/2012

Description:
Patients:
This phase 2 study involved 41 female, HER2-positive metastatic breast cancer patients who had been previously treated with trastuzumab. The median patient age was 54 years.

Treatment:
Patients were treated with biologic therapy agent afatinib, which is a tyrosine kinase inhibitor that inhibits the HER2 and EGFR proteins.

Toxicities:
The most severe toxicities were of grade 3 and included diarrhea, rash, and vomiting.

Results:
The median overall survival was 14 months.

Support:
This study was supported by Boehringer Ingelheim, makers of afatinib.

Correspondence: Dr. Nancy Lin; email: Nancy_Lin@dfci.harvard.edu

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