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Lung Cancer treatment details. Chemotherapy. Aichi Cancer Center Aichi Hospital, Okazaki, Japan



Survival: 5.9 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: Japan
   
City/State/Province: Okazaki
   
Hospital: Aichi Cancer Center Aichi Hospital
   
Journal: Link
   
Date: 2/2012

Description:
Patients:
This phase 2 study involved advanced non-small cell lung cancer patients with no previous chemotherapy who were divided into two separate treatment groups. In group A, there were 41 patients with a median age of 65 years and 73.2% male. Group B had 43 patients with a median age of 67 years and 72.1% male.

Treatment:
Patients in group A were treated with the chemotherapy agents carboplatin and paclitaxel.

Patients in group B were treated with the chemotherapy agents gemcitabine and vinorelbine.

Toxicities:
There was one treatment-related death due to pneumonia in group A. Grade 3 nausea and neurotoxicity were also reported.

Three treatment-related deaths due to infection and shock were reported for group B. Grade 4 liver toxicity was also reported.

Results:
The median overall survival for groups A and B was 5.9 and 6.0 months, respectively.

Support:
One of the authors has received some funding from the pharmaceutical company AstraZeneca.

Correspondence: Dr. Hiroshi Saito; email: hsaito@acc-aichi.com

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