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Melanoma treatment details. Immunotherapy. University of Minnesota, Minneapolis, MN, United States



Survival: 10.0 months
   
Toxicity Grade: 3
   
Treatments: Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Minneapolis, MN
   
Hospital: University of Minnesota
   
Journal: Link
   
Date: 12/2012

Description:
Patients:
This phase 2 study involved advanced melanoma patients who were divided into two separate treatment groups. There were 11 patients in group A and 10 patients in group B. Age and gender information was not provided.

Treatment:
Patients in group A were treated with the immunotherapy agent interleukin-2 (IL-2; stimulates the immune system) and the vaccine called allogeneic large multivalent immunogen (LMI) vaccine, which directs the immune system to target melanoma cells.

Patients in group B were treated with IL-2 alone.

Toxicities:
The most severe toxicity in group A was grade 4 deep vein thrombosis (blood clot). Grade 3 nausea, weakness, back pain, and abdominal pain were also reported.

The most severe toxicities in group B were of grade 3 and included nausea, weakness, back pain, and abdominal pain.

Results:
The median overall survival for groups A and B was 11.9 and 10.0 months, respectively.

Correspondence: Dr. Arkadiusz Z. Dudek; email: dudek002@umn.edu

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