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Prostate Cancer treatment details. Chemotherapy. Daniel den Hoed Cancer Center, Rotterdam, Netherlands



Survival: 18.4 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: Netherlands
   
City/State/Province: Rotterdam
   
Hospital: Daniel den Hoed Cancer Center
   
Journal: Link
   
Date: 11/2012

Description:
Patients:
This study involved metastatic castration-resistant prostate cancer patients with metastases to the bone who were divided into two separate treatment groups. There were 301 patients in group A with a median age of 69 years. Group B had 291 patients with a median age of 68 years.


Treatment:
Patients in group A were treated with the chemotherapy agent docetaxel.
Patients in group B were treated with docetaxel and the drug risedronate, which inhibits bone resorption (degradation).

Toxicities:
There were two treatment-related deaths due to infection in group A. Grade 3-4 diarrhea and neurotoxicity were also reported.

The most severe toxicities were of grade 4 and included grade 3-4 neutropenia and neurotoxicity.

Results:
The median overall survival for groups A and B was 18.4 and 19.2 months, respectively.

Support:
This study was supported by Sanofi-Aventis, makers of risedronate.

Correspondence: Dr. H.J. Meulenbeld; email: h.meulenbeld@erasmusmc.nl

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