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Bladder Cancer treatment details. Chemotherapy. Athens University Medical School, Athens, Greece



Survival: 19.0 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Adriamycin
Methotrexate
Country: Greece
   
City/State/Province: Athens
   
Hospital: Athens University Medical School
   
Journal: Link
   
Date: 4/2013

Description:
Patients:
This phase 3 study involved advanced urothelial cancer patients who were divided into two separate treatment groups. Group A consisted of 63 patients with a median age of 66 years and 84.1% male. Group B had 63 patients with a median age of 65 years and 87.3% male.

Treatment:
Patients in group A were treated with the chemotherapy agents methotrexate, vinblastine, adriamycin, and cisplatin.

Patients in group B were treated with the chemotherapy agents gemcitabine and cisplatin.

Toxicities:
There were two treatment-related deaths in group A due to infection. Grade 4 neutropenia and grade 3 fatigue were also reported.

The most severe toxicities in group B were of grade 4 and included anemia and neutropenia. Grade 3 infection and fatigue were also reported.

Results:
The median overall survival for groups A and B was 19 and 18 months, respectively.

Correspondence: Dr. A. Bamias; email: abamias@med.uoa.gr

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