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Brain Cancer treatment details. Biologic therapy. National Cancer Institute, National Institutes of Health, Bethesda, MD, United States



Survival: 4.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Bethesda, MD
   
Hospital: National Cancer Institute, National Institutes of Health
   
Journal: Link
   
Date: 1/2013

Description:
Patients:
This phase 2 study involved recurrent glioblastoma patients who were divided into two separate patient groups. Group A consisted of 32 patients with a median age of 57 years who were not previously treated with bevacizumab; 72% were male. Group B consisted of 31 patients with a median age of 54 years who were previously treated with but resistant to bevacizumab; 68% were male.

Treatment:
Patients in groups A and B were treated with the biologic therapy agent sunitinib, which is a small molecule inhibitor of VEGF receptors and interferes with cancer cell growth.

Toxicities:
Toxicity information was not separated based on patient group because both groups received the same drug and dose. There was one treatment-related death due to pneumonia in this study. Bleeding, neutropenia, and lymphopenia were also reported.

Results:
The median overall survival for groups A and B was 9.4 and 4.37 months, respectively.

Correspondence: Dr. Nguyen Kreisl; email: kreislt@mail.nih.gov

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