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Breast Cancer treatment details. Biologic therapy. Chemotherapy. Mayo Clinic, Jacksonville, FL, United States



Survival: 28.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Jacksonville, FL
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 4/2012

Description:
Patients:
This phase 2 study involved 46 HER+ metastatic breast cancer patients (all female) with a median age of 60 years.

Treatment:
Patients were treated with the chemotherapy agents vinorelbine and capecitabine, as well as the biologic therapy agent trastuzumab, a monoclonal antibody that interferes with the HER2 receptor to slow cancer cell growth.

Toxicities:
There was one death due to gastrointestinal tract hemorrhage during this study. Grade 4 neutropenia, leukopenia, and diarrhea were reported.

Results:
The median overall survival was 28.5 months.

Support:
This study was partially supported by the pharmaceutical company Genentech.

Correspondence: Dr. Winston Tan; email: tan.winston@mayo.edu

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