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Rectal Cancer treatment details. Chemotherapy. Radiation. Surgery. Stanford University Medical Center, Stanford, California, United States

Survival: ?
Toxicity Grade: 3
Treatments: Chemotherapy
Drugs: Camptosar
Country: United States
City/State/Province: Stanford, California
Hospital: Stanford University Medical Center
Journal: Link
Date: 1/2003

Patients: Thirty-two patients (21 men, 11 women) with biopsy-proven adenocarcinoma of the rectum were enrolled in this Phase II study. All patients were staged at T3.

Treatment: Treatment consisted of radiotherapy with concurrent chemotherapy, CPT-11 (camptosar) and 5-FU (FUDR), followed by surgical resection (6-10 weeks after completing chemoradiotherapy).

Toxicity: Acute toxicity was frequently observed, and 18 patients required either a chemotherapy dose reduction or RT interruption of more than days. One patient withdrew because of diarrhea and abdominal cramping (Grade III) after 10 days of treatment. Other grade 3 toxicities included: mucositis, diarrhea, rectal sores, and nausea/vomiting.

Results: Twenty-three of the thirty-two patients were downstaged. Overall survival was not discussed.

Correspondence: Vivek K. Mehta, MD,

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