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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. Hormone. Weill Cornell Medical College, New York, NY, United States



Survival: 10.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
Hormone
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Weill Cornell Medical College
   
Journal: Link
   
Date: 8/2012

Description:
Patients:
This study involved 15 relapsed or refractory diffuse large B-cell lymphoma patients who had previously received chemotherapy. The median patient age was 64 years; no gender information was provided.

Treatment:
Patients were treated with the steroid hormone dexamethasone, the chemotherapy agents ifosfamide, cisplatin, and etoposide, and the biologic therapy agents rituximab (monoclonal antibody for CD20) and bortezomib (a proteasome inhibitor).

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 neutropenia, thrombocytopenia, and anemia. Grade 3 nausea, fatigue, and mucositis were also reported.

Results:
The median overall survival was 10 months.

Support:
One of the study drugs, bortezomib, was provided by Millennium Pharmaceuticals.

Correspondence: Dr. Richard R. Furman; email: rrfurman@med.cornell.edu

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