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Brain Cancer treatment details. Biologic therapy. Radiation. Institut Claudius Regaud, Toulouse, France



Survival: 18.5 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
Radiation
   
Drugs:
Country: France
   
City/State/Province: Toulouse
   
Hospital: Institut Claudius Regaud
   
Journal: Link
   
Date: 4/2013

Description:
Patients:
This phase 2 study involved 27 newly diagnosed glioblastoma patients who had not been previously treated. The median patient age was 59 years and 18 were male.

Treatment:
Patients were treated with radiation therapy and the biologic therapy agent tipifarnib, which is an inhibitor of a protein called farnesyltransferase and may help to lessen cancer cell resistance to radiation.

Toxicities:
The most severe toxicities were of grade 3 and included skin rash, neurologic disorders (seizure and speech impairment), and pain.

Results:
The median overall survival was 18.5 months.

Support:
This study was supported by the pharmaceutical company Janssen-Cilag.

Correspondence: Dr. Elizabeth Cohen-Jonathan Moyal; email: moyal.elizabeth@claudiusregaud.fr

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