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Brain Cancer treatment details. Biologic therapy. Radiation. University Clinic Heidelberg, Heidelberg, Germany



Survival: 15.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Radiation
   
Drugs:
Country: Germany
   
City/State/Province: Heidelberg
   
Hospital: University Clinic Heidelberg
   
Journal: Link
   
Date: 8/2013

Description:
Patients:
This phase 2 study involved 57 patients with newly diagnosed glioblastoma without the mutation called MGMT promoter hypermethylation. The median patient age was 57.6 years and 36 were male.

Treatment:
Patients were treated with radiation therapy and the biologic therapy agent enzastaurin, which is a kinase inhibitor.

Toxicities:
Treatment-related deaths due to tumor hemorrhage, infection, and heart toxicity were reported. Grade 3 fatigue was also reported.

Results:
The median overall survival was 15 months.

Support:
This study was supported by Eli Lilly and Company.

Correspondence: Dr. Wolfgang Wick; email: wolfgang.wick@med.uni-heidelberg.de

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