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Colon Cancer treatment details. Chemotherapy. Vienna University Medical School, Vienna, Austria



Survival: 16.5 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: Austria
   
City/State/Province: Vienna
   
Hospital: Vienna University Medical School
   
Journal: Link
   
Date: 1/2002

Description:
Patients: This Phase II study involved 92 patients with previously untreated advanced colorectal cancer. Forty-six patients were randomized to group A (arm A) and forty-six patients were randomized to group B (arm B).

Treatment: Patients in group A received oxaliplatin plus irinotecan. Patients in group B received raltitrexed. Upon development of progressive disease (i.e. growth of tumor), second-line treatment with the opposite arm was administered.

Toxicity: Grade 3-4 toxicities in group B included: leucopenia, neutropenia, thrombocytopenia, anemia, infection, stomatitis, diarrhea, and liver function.

Results: With a median follow-up of 15 months, the median overall survival (measured from the date of randomization) was 16.5 months for patients in group B.

Correspondence: Werner Scheithauer, MD

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