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Colon Cancer treatment details. Chemotherapy. Institut de CancÚrologie de l'Ouest, Nantes, France

Survival: 9.8 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: France
City/State/Province: Nantes
Hospital: Institut de CancÚrologie de l'Ouest
Journal: Link
Date: 1/2013

This phase 3 study involved metastatic colorectal cancer patients, previously treated with bevacizumab and chemotherapy, who were divided into two separate treatment groups. There were 409 patients with a median age of 63 years in group A; 65% were male. Group B had 411 patients with a median age of 63 years and 63% male.

Patients in group A were treated with the biologic therapy agent bevacizumab and chemotherapy with either irinotecan or oxaliplatin.

Patients in group B were given chemotherapy only, with either irinotecan or oxaliplatin.

Treatment-related deaths (4) due to intestinal bleeding, stroke, sudden death, and neutropenia were reported in group A. Grade 3-4 diarrhea, weakness, and nausea/vomiting were also reported.

Treatment-related deaths (3) due to intestinal perforation, general physical health deterioration, and kidney failure were reported in group B. Grade 3-4 neutropenia, diarrhea, and weakness were also reported.

The median overall survival for groups A and B was 11.2 and 9.8 months, respectively.

This study was supported by the pharmaceutical company F. Hoffmann-La Roche.

Correspondence: Dr. Stefan Kubicka; email:

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