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Colon Cancer treatment details. Chemotherapy. Antwerp University Hospital, Edegem, Belgium



Survival: 8.8 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Leucovorin
Country: Belgium
   
City/State/Province: Edegem
   
Hospital: Antwerp University Hospital
   
Journal: Link
   
Date: 2/2013

Description:
Patients:
This phase 2 study involved previously treated metastatic colorectal cancer patients who were separated into two treatment groups. Group A consisted of 95 patients with a median age of 56 years and 63% male. Group B had 49 patients with a median age of 55 years and 49% male.

Treatment:
Patients in group A were treated with the chemotherapy combination called FOLFIRI (irinotecan, leucovorin, 5-fluorouracil) and the biologic therapy agent trebananib, which is an inhibitor of the angiopoietin proteins and interferes with tumor growth.

Patients in group B were treated with the chemotherapy combination called FOLFIRI (irinotecan, leucovorin, 5-fluorouracil) only.

Toxicities:
In group A, there were six reported deaths due to adverse events including swelling of the lungs, diarrhea, and heart attack. Grade 3-4 neutropenia and fatigue were also reported.

There were three deaths in group B due to adverse events including cardiorespiratory arrest. Grade 3-4 neutropenia, vomiting, and abdominal pain were also reported.

Results:
The median overall survival for groups A and B was 11.9 and 8.8 months, respectively.

Support:
This study was partially supported by Amgen, Inc.

Correspondence: Dr. M Peeters; email: Marc.Peeters@uza.be

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