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Liver Cancer treatment details. Biologic therapy. University of Barcelona, Barcelona, Spain



Survival: 13.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: Spain
   
City/State/Province: Barcelona
   
Hospital: University of Barcelona
   
Journal: Link
   
Date: 6/2013

Description:
Patients:
This phase 2 study involved 36 hepatocellular carcinoma patients who had been previously treated with sorafenib. The median patient age was 61 years and 89% were male.

Treatment:
Patients were treated with the biologic therapy agent called regorafenib, which is a kinase inhibitor that interferes with cancer cell growth.

Toxicities:
There were study-related deaths due to cerebral hemorrhage and bleeding reported for this study. Grade 3-4 fatigue, hand-foot skin reaction, and diarrhea were also reported.

Results:
The median overall survival was 13.8 months.

Support:
This study was funded by Bayer HealthCare Pharmaceuticals.

Correspondence: Dr. Jordi Bruix; email: jbruix@clinic.ub.es

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