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Lung Cancer treatment details. Chemotherapy. Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangzhou, China



Survival: 18.3 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: China
   
City/State/Province: Guangzhou
   
Hospital: Guangdong Lung Cancer Institute, Guangdong General Hospital
   
Journal: Link
   
Date: 9/2012

Description:
Patients:
This phase 3 study involved untreated advanced non-small cell lung cancer patients who were divided into two separate treatment groups. Of the total patient population, 78.5% were female and 82.5% were less than 65 years of age. There were 184 patients in group A and 188 in group B.

Treatment:
Patients in group A were treated with the biologic therapy agent gefitinib, which is an inhibitor of EGFR and interferes with cancer cell growth.

Patients in group B were treated with the chemotherapy agents carboplatin and paclitaxel.

Toxicities:
The most severe toxicities in group A were of grade 4 and included grade 3-4 diarrhea, rash, and liver toxicity.

There were two treatment-related deaths in group B due to lung infection and pneumonia. Grade 3-4 leukopenia, neutropenia, vomiting, and neurotoxicity were also reported.

Results:
The median overall survival for groups A and B was 18.1 and 18.3 months, respectively.

Support:
This study was supported by AstraZeneca, makers of gefitinib.

Correspondence: Dr. Yi-Long Wu; email: syylwu@live.cn

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