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Melanoma treatment details. Biologic therapy. Chemotherapy. Newcastle University, Newcastle upon Tyne, United Kingdom



Survival: 9.9 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: Newcastle upon Tyne
   
Hospital: Newcastle University
   
Journal: Link
   
Date: 5/2013

Description:
Patients:
This phase 2 study involved 46 advanced metastatic melanoma patients. The average patient age was 51.5 years (range of 19-82) and 52% were male.

Treatment:
Patients were treated with the chemotherapy agent temozolomide and the biologic therapy agent rucaparib, which is a poly(ADP ribose) polymerase (PARP) inhibitor that may enhance the effectiveness of chemotherapy drugs.

Toxicities:
There were two treatment-related deaths due to infection and liver and kidney failure. Grade 3-4 neutropenia, leucopenia, fatigue, and headache were also reported.

Results:
The median overall survival was 9.9 months.

Support:
This study was supported by Pfizer.

Correspondence: Dr. Ruth Plummer; email: ruth.plummer@ncl.ac.uk

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