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Bladder Cancer treatment details. Biologic therapy. Cleveland Clinic, Cleveland, OH, United States

Survival: 6.8 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Cleveland, OH
Hospital: Cleveland Clinic
Journal: Link
Date: 9/2009

This phase 2 study involved 22 advanced urothelial carcinoma patients who had received one prior chemotherapy regimen. The median patient age was 66 years and 14 were male.

Patients were treated with the biologic therapy agent sorafenib, which is a kinase inhibitor that interferes with cancer cell growth.

The most severe toxicities were of grade 4 and included pulmonary embolism. Grade 3 hand-foot skin reaction and fatigue were also reported.

The median overall survival was 6.8 months.

Correspondence: Dr. Robert Dreicer; email:

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