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Bladder Cancer treatment details. Chemotherapy. Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, United States



Survival: 8.2 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Philadelphia, PA
   
Hospital: Abramson Cancer Center of the University of Pennsylvania
   
Journal: Link
   
Date: 9/2009

Description:
Patients:
This phase 2 study involved 151 metastatic or locally advanced urothelial carcinoma patients who had received prior platinum-based chemotherapy. The median patient age was 66 years and 80.1% were male.

Treatment:
Patients were treated with the chemotherapy agent vinflunine.

Toxicities:
There were two treatment-related deaths due to heart attack and sepsis (infection). Grade 3/4 neutropenia, leukopenia, and constipation were also reported.

Results:
The median overall survival was 8.2 months.

Support:
This study was supported by Bristol-Myers Squibb.

Correspondence: Dr. David J. Vaughn; email: david.vaughn@uphs.upenn.edu

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