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Brain Cancer treatment details. Radiation. Linköping University, Linköping, Sweden



Survival: 7.5 months
   
Toxicity Grade: 5
   
Treatments: Radiation
   
Drugs:
Country: Sweden
   
City/State/Province: Linköping
   
Hospital: Linköping University
   
Journal: Link
   
Date: 9/2012

Description:
Patients:
This phase 3 study involved newly diagnosed glioblastoma patients, all older than 60 years, who were divided into three separate treatment groups. Group A was composed of 93 patients with a median age of 70 years and 59% male. Group B had 98 patients with a median age of 70 years and 51% male. There were 100 patients in group C with a median age of 70 years and 68% male.

Treatment:
Patients in group A were treated with the chemotherapy agent temozolomide.
Patients in group B were treated with hypofractionated radiotherapy.
Patients in group C were treated with standard radiotherapy.

Toxicities:
There was one treatment-related death in group A due to bleeding. Grade 4 neutropenia and thrombocytopenia were also reported.

The most severe toxicities in group B were of grade 4 and included seizures and fatigue.

There was one treatment-related death due to infection reported in group C. Grade 3 seizures were also reported.

Results:
The median overall survival rates for groups A, B, and C were 6.0, 8.3, and 7.5 months, respectively.

Support:
This study was partially supported by Merck.

Correspondence: Dr. Annika Malmström; email: annika.malmstrom@lio.se

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