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Rectal Cancer treatment details. Chemotherapy. Centre Hospitalier Lyon-Sud, Pierre-Benite, France

Survival: ?
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Adrucil
Country: France
City/State/Province: Pierre-Benite
Hospital: Centre Hospitalier Lyon-Sud
Journal: Link
Date: 5/2001

Patients: This Phase I study involved 17 rectal adenocarcinoma patients. Patients had T4 rectal carcinoma, T1-T3 disease with colostomy refusal, or potentially operable T2/T3 M1 requiring local treatment.

Treatment: Treatment consisted of pelvic radiotherapy with chemotherapy oxaliplatin (eloxatin), L-folinic acid (leucovorin), and fluorouracil (5-FU, adrucil).

Toxicity: Only one patient had any grade 4 toxicities (diarrhea). Other toxicities (grades 1-3) included: hematologic, neurosensory, gastrointestinal, and weight loss.

Results: Survival was not discussed although there were seven complete, seven partial, and three minor responses.

Support: Supported (in part) by grants from Sanofi-Synthelabo and Wyeth-Lederle.

Correspondence: Jean-Pierre Gerard, MD

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