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Liver Cancer treatment details. Biologic therapy. Massachusetts General Hospital, Boston, MA, United States



Survival: 11.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Massachusetts General Hospital
   
Journal: Link
   
Date: 3/2013

Description:
Patients:
This phase 2 study involved 17 advanced hepatocellular carcinoma patients. The median patient age was 66 years and 88% were male.

Treatment:
Patients were treated with the biologic therapy agent called cediranib, which is a tyrosine kinase inhibitor that interferes with tumor blood supply.

Toxicities:
There was one reported death due to brain herniation that may have been related to treatment. Grade 4 pulmonary embolism and grade 3 fatigue were also reported.

Results:
The median overall survival was 11.7 months.

Support:
This study was partially supported by AstraZeneca, makers of cediranib.

Correspondence: Dr. Andrew X. Zhu; email: azhu@partners.org

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