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Liver Cancer treatment details. Biologic therapy. Massachusetts General Hospital, Boston, MA, United States

Survival: 11.7 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Boston, MA
Hospital: Massachusetts General Hospital
Journal: Link
Date: 3/2013

This phase 2 study involved 17 advanced hepatocellular carcinoma patients. The median patient age was 66 years and 88% were male.

Patients were treated with the biologic therapy agent called cediranib, which is a tyrosine kinase inhibitor that interferes with tumor blood supply.

There was one reported death due to brain herniation that may have been related to treatment. Grade 4 pulmonary embolism and grade 3 fatigue were also reported.

The median overall survival was 11.7 months.

This study was partially supported by AstraZeneca, makers of cediranib.

Correspondence: Dr. Andrew X. Zhu; email:

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